Quinacrine (hydrochloride hydrate)
CAY-15041-100 100 mg
Data Sheet: 
SDS:
SDS:
Formulation
A crystalline solid
Purity
≥95%
MW
472,9
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Quinacrine is an acridine compound with diverse biological activities that has also been used as a stain for DNA and RNA in fixed cells and for fluorescent tracking of acidic vesicles, such as lysosomes, in live cells.{23969,23970,23759,23972} It has anti-protozoal properties, potently prevents misfolding of prion protein (EC50 = 0.3 μM), blocks voltage-dependent sodium channels (IC50 = 3.3 μM), and inhibits aldehyde oxidase (IC50 = 3.3 μM).{23969,23970,23759,23972} Quinacrine is also an effective riboflavin antagonist, associating with the riboflavin-binding protein (Ki = 6.7 μM), and an inhibitor of P-glycoprotein (EC50 = 14.4 μM).{23968,23971} At much higher doses, quinacrine inhibits phospholipase A2 activity.{23974,12506} Quinacrine binds to nucleic acids and has been used in fixed cells to stain DNA and RNA with excitation/emission maxima of 436/525 nm, respectively.{38900} In live cells, it is taken up into acidic vesicles, such as lysosomes, and can be used to for long-term imaging with an excitation of 458 nm and emission in the 470-580 nm range.{38901}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
