DT-061
CAY-42118-10 10 mg
Synonyms: Small Molecule Activator of PP2A|SMAP
Data Sheet: 
SDS:
SDS:
CAS
1809427-19-7
Formulation
A solid
Purity
≥98%
MW
520,521809
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A PP2A activator; increases the affinity of PP2A-B56α to a PP2A-A and PP2A-C dimer; does not induce phosphate release in a cell-free assay using B55α, B56α, or B56ε as the regulatory subunits; decreases Cer and hexosylceramide molar ratios and increases SM molar ratios in relation to PC in MCF-7 cells cultured with sphingosine; disrupts Golgi and endoplasmic reticulum integrity in HeLa cells; reduces tumor volume in an NCI H358 NSCLC mouse xenograft using cells that express wild-type PP2A-A but not those that express an PP2A-AR183W at 5 mg/kg; increases allograft survival in a murine heart transplantation model at 5 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
