cGAMP ELISA Kit

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that detects the presence of nucleic acids in the cytosol of mammalian cells as an indicator of bacterial or viral infection. cGAS catalyzes the synthesis of a second messenger, 2’3’-cGAMP, from cytosolic ATP and GTP in response to dsDNA binding. 2’3’-cGAMP then binds tightly to the adaptor protein STING (stimulator of interferon genes), resulting in the recruitment of TBK1 and subsequent IRF3 phosphorylation. IRF3 induces the transcription and translation of type I interferon, a potent antiviral cytokine. Activation of cGAS and the production of 2’3’-cGAMP are important in host defense but also may play role in autoimmune or inflammatory diseases. Modulation of cGAS activity with subsequent inhibition of induction of 2’3’-cGAMP formation is an active target of pharmacological intervention.

Synonyms: 2'3'-Cyclic GMP-AMP, and Guanosine-Adenosine 2',3'-cyclic monophosphate