anti-Symmetric Dimethyl-Histone H4 (Arg3), Rabbit Monoclonal (RM459)

  REV-31-1351-00-C025 25 µg

Data Sheet:    

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Human, All Vertebrates  

WB, Multiplex  

Rabbit  

This antibody reacts to Histone H4 symmetric dimethylated at arginine 3 (R3me2s). No cross-reactivity with unmodified arginine 3, monomethylated or asymmetric dimethylated arginine 3, or other methylated arginine in Histone H4 has been shown.  

RM459  

Protein A purified.  

BLUE ICE  

-20°C  

Stable for at least 1 year after receipt when stored at -20°C.  

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Description

 

Recombinant Antibody. This antibody reacts to Histone H4 symmetric dimethylated at arginine 3 (R3me2s). No cross-reactivity with unmodified arginine 3, monomethylated or asymmetric dimethylated arginine 3, or other methylated arginine in Histone H4 has been shown. Applications: WB, Multiplex. Clone: RM459. Isotype: Rabbit IgG. Formulation: Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H4 is involved with the structure of the nucleosome of the 'beads on a string' organization. Histone proteins are highly post-translationally modified. Covalently bonded modifications include acetylation and methylation of the N-terminal tails. These modifications may alter expression of genes located on DNA associated with its parent histone octamer. Histone H4 is an important protein in the structure and function of chromatin, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.

 

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