VPS34-IN-19
CAY-41357-100 100 mg
Synonyms: Compound 19|Vacuolar Protein Sorting 34 Inhibitor 19|VPS Inhibitor 19
Data Sheet: 
SDS:
SDS:
CAS
1383716-46-8
Formulation
A solid
Purity
≥98%
MW
391,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of VPS34 (IC50 = 15 nM); selective for VPS34 over PI3Kδ (IC50 = 802 nM) and PI3Kα, PI3Kβ, and PI3Kγ (IC50s = >802 nM for all); increases intratumoral levels of LC3-II, a marker of autophagy but does not reduce tumor volume in an RKO colon cancer mouse xenograft model at 50 mg/kg twice per day; reduces SARS-CoV-2 viral titers in isolated human lung tissue at 2.5 and 5 µM
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
