UNC569
CAY-22966-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
1350547-65-7
Formulation
A crystalline solid
Purity
≥98%
MW
396,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A TAM family kinase inhibitor (IC50s = 2.9, 37, and 48 nM for Mer, Axl, and Tyro3, respectively); antiproliferative against ALL cells (IC50s = 0.5 and 1.2 μM for 697 and Jurkat cell lines, respectively); inhibits Mer phosphorylation (IC50s = 141 and 193 nM in 697 and Jurkat cell lines, respectively); decreases tumor burden by 47.8% relative to controls in human MYC transgenic zebrafish (4 μM); delays leukemia onset, reduces CNS infiltration, and prolongs survival of mice implanted with patient-derived Mer-expressing ALL primary cells (10 mg/kg)
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
