UCL-TRO-1938
CAY-39118-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
2919575-27-0
Formulation
A solid
Purity
≥98%
MW
456,58282
Shipment
-20
Long Term Storage
-20
Shelf Life
1095
Description
An allosteric PI3Kα activator; It binds to PI3Kα in an SPR assay (Kd = 36 µM) and induces PI3Kα activation in a cell-free assay at 25 and 50 µM; increases PtdIns-(3,4,5)-P3 and phosphorylated Akt levels in MEFs (EC50s = 5 and 2-4 µM, respectively); increases tissue survival and decreases infarct size in perfused rat hearts; reduces infarct size in a mouse model of LAD coronary artery occlusion-induced ischemia-reperfusion injury at 10 mg/kg; increases the number of motor neurons and innervation of neuromuscular junctions in a rat model of sciatic nerve crush injury
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
