Tofacitinib (citrate)
CAY-11598-5 5 mg
CAS
540737-29-9
Formulation
A crystalline solid
Purity
≥98%
MW
504,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A JAX inhibitor (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively); selective for JAK1-3 over ROCK2 and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM); inhibits IL-2-mediated phosphorylation of JAK3 and STAT5 (30 ng/ml); prevents rejection and prolongs survival in murine and cynomolgus monkey models of heterotopic heart and kidney transplantation
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
