Thiorphan
CAY-15600-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
76721-89-6
Formulation
A crystalline solid
Purity
≥95%
MW
253,3
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A NEP inhibitor (IC50 = 0.007 µM); inhibits NEP over NEP2 (IC50 = 22 µM) and ACE and ECE1 (Kis = >100 and >10,000 nM, respectively, in cell-free assays); increases bradykinin-induced relaxation of isolated porcine coronary artery rings precontracted with potassium chloride under hypoxic, but not normoxic, conditions at 10 µM; reduces pentagastrin-induced increases in gastric acid output by 64% in rats at 50 µg i.c.v., but not 1.7 and 17 mg/kg i.v.; increases cortical levels of insoluble Aβ40 and decreases time spent in the platform quadrant in the Morris water maze, indicating impaired reference memory, in rats at 2 mg/ml i.c.v.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
