TNO155
CAY-32525-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
1801765-04-7
Formulation
A crystalline solid
Purity
≥98%
MW
421,9
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A SHP-2 inhibitor (IC50 = 0.011 µM); selective for SHP-2 over a panel of 52 kinases and phosphatases (IC50s = >10 µM for all); decreases phosphorylation of ERK in, and inhibits proliferation of, KYSE-520 human esophageal cancer cells (IC50s = 0.011 and 0.1 µM, respectively); acts synergistically with dabrafenib and trametinib to inhibit proliferation of B-RAFV600E-expressing HT-29, RKO, and MDST8 colorectal cancer cells; reduces tumor growth in a KYSE-520 mouse xenograft model at 2.5, 10, and 20 mg/kg twice per day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
