TNF-R1 (human):Fc (human) (rec.) MultiPack
AG-40B-0074-3050 3 x 50 ug
Synonyms: p55; CD120a; TNFRSF 1A; Tumor Necrosis Factor Receptor Superfamily Member 1A; TNF Receptor 1
Data Sheet: 
SDS:
SDS:
Reactivity
Human, Mouse
Source / Host
HEK 293 cells
Specificity
Binds human and mouse TNF-alpha.
Purity
>95% (SDS-PAGE)
MW
~60kDa (reducing SDS-PAGE)
Shipment
BI
Short Term Storage
+4°C
Long Term Storage
-20°C
Shelf Life
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Description
Protein. The extracellular domain of human TNF-R1 (aa 22-211) is fused to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds human and mouse TNF-alpha. Purity: >95% (SDS-PAGE). TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
