TG6-10-1
CAY-23444-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
1415716-58-3
Formulation
A crystalline solid
Purity
≥98%
MW
448,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A potent EP2 receptor antagonist (Kb = 17.8 nM in C6 glioma cells overexpressing human EP2); 300-, 25-, and 10-fold selective for EP2 over other human EP3-4, FP and TP, and DP1 receptors, respectively; selective for EP2 over a panel of 40 enzymes, ion channels, receptors, and neurotransmitter transporters (IC50s >10 μM); increases survival, decreases weight loss, prevents induction of IL-1β, IL-6, TNF-α, and MCP-1/CCL2 mRNA, and inhibits neuronal cell death in the hippocampus in mouse and rat models of status epilepticus induced by pilocarpine and diisopropyl fluorophosphate, respectively
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
