Simurosertib
CAY-32519-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
1330782-76-7
Formulation
A solid
Purity
≥98%
MW
341,43186
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of Cdc7 kinase (IC50 = 0.26 nM); selective for Cdc7 over Cdk2 and ROCK1 (IC50s = 6,300 and 430 nM, respectively); inhibits phosphorylation of MCM2 in HeLa cells (IC50 = 17 nM); reduces proliferation of COLO 205 cells (EC50 = 81 nM); inhibits the growth of a wide variety of cancer cells (GI50s = 30.2->10,000 nM); reduces intratumor levels of phosphorylated MCM2 in COLO 205 and SW948 mouse xenograft models at 80 mg/kg and reduces tumor growth in the same models when administered at doses of 40 or 60 mg/kg twice per day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
