SSR 240612
CAY-25544-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
464930-42-5
Formulation
A crystalline solid
Purity
≥95%
MW
793,41168
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A selective, non-peptide bradykinin B1 receptor antagonist (Kis = 0.48-0.73 and 358-481 nM for B1 and B2 receptors, respectively); inhibits the contraction of rabbit aorta and rat ileum induced by des-Arg9-BK ex vivo; reduces tissue damage and neutrophil accumulation in a rat model of splanchnic artery occlusion/reperfusion-induced intestinal injury; inhibits des-Arg9-BK-induced paw edema in mice at 3 and 10 mg/kg; reduces fibrosis in a unilateral ureteral obstruction mouse model of kidney fibrosis; reduces mean arterial blood pressure in two rat models of hypertension; reduces plasma glucose and insulin levels in a glucose-fed rat model of insulin resistance; exhibits analgesic properties in several rodent models of hyperalgesia
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
