Ripretinib
CAY-33782-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
1442472-39-0
Formulation
A solid
Purity
≥95%
MW
510,358443
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A KIT and PDGFRα inhibitor (IC50s = 3 and 3.6 nM, respectively); selective for KIT and PDGFRα over a panel of 300 kinases (IC50s = >100 nM); inhibits DDR2, VEGFR2, PDGFRβ, and Tie2 (IC50s = V654A, KITT670I, KITD816H, KITD816V, and PDGFRαD842V (IC50s = 11, 9.2, 18, 25, and 36 nM, respectively); induces apoptosis in ROSA wild-type, and KITD816V- or KITK509I-expressing mast cells; reduces tumor growth and increases survival in an imatinib-resistant PDX mouse model of GISTs at 50 and 100 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
