RO8994
CAY-25674-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
1309684-94-3
Formulation
A crystalline solid
Purity
≥98%
MW
613,506203
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of the protein-protein interaction between MDM2 and p53 (IC50 = 5 nM in a p53-MDM2 HTRF binding assay); inhibits the proliferation of SJSA-1, RKO, and HCT116 cells (average IC50 = 20 nM); increases apoptosis in SJSA-1 cells in a concentration-dependent manner; reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model at 1.56 and 6.25 mg/kg, respectively.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
