RIPA-56
CAY-33431-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
1956370-21-0
Formulation
A crystalline solid
Purity
≥98%
MW
221,2955
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A RIPK1 inhibitor (IC50 = 13 nM); selective for RIPK1 over RIPK3 at 10 µM, as well as over a panel of additional kinases at 2 µM; inhibits Z-VAD-FMK-induced necrosis in HT-29 cells (EC50 = 28 nM); reduces TNF-α-induced lethality and protects against TNF-α-induced organ damage in a mouse model of SIRS at 6 mg/kg; reduces spinal cord demyelination and BBB breakdown in a mouse model of EAE; reduces hepatic inflammatory cell infiltration and fibrosis, as well as body weight gain and total fat mass, in a mouse model of high-fat diet-induced NASH at 300 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
