RECTAS
CAY-38322-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
101862-47-9
Formulation
A solid
Purity
≥98%
MW
249,65632
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A pre-mRNA splicing modulator; corrects aberrant splicing in a SPREADD using HeLa cells expressing IKBKAP with an IVS20 + 6T>C point mutation; restores the modification of cytoplasmic tRNAs with uridine in the wobble position in primary human fibroblasts from patients with FD to the same level as in primary human fibroblasts from carriers of the FD mutation at 2 µM; increases the levels of correctly spliced PARK7 mRNA in neural precursor cells differentiated from fibroblasts of patients with the homozygous PARK7 c.192G>C exonic splicing mutation in combination with phenylbutyric acid; intratumoral administration decreases tumor volume and increases survival and the number of tumor-infiltrating CD8+ T cells in an MC-38 murine colon carcinoma model
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
