PHA-793887
CAY-18388-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
718630-59-2
Formulation
A crystalline solid
Purity
≥95%
MW
361,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A CDK inhibitor (IC50s = 8, 8, 5, and 10 nM for Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk7/cyclin H, respectively); selective for these CDKs over Cdk1/cyclin B, Cdk4/cyclin D1, Cdk9/cyclin T1, and GSK3β (IC50s = 60, 62, 138, and 79 nM, respectively), as well as a panel of 36 other kinases at 10 µM; inhibits the proliferation of A2780, HCT116, and BxPC-3 cells (IC50 = 0.088, 0.163, and 3.444 µM, respectively); inhibits reactivation of latent HIV-1 induced by prostratin, panobinostat, or JQ-1 in 24ST1NLESG cells (IC50s = 88, 163, and 3,444 nM, respectively); reduces tumor growth and increases survival in HL-60 and K562 leukemia mouse xenograft models at 20 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
