PF-573228
CAY-14924-5 5 mg
Synonyms: FAK Inhibitor II|Focal Adhesion Kinase Inhibitor II
Data Sheet: 
SDS:
SDS:
CAS
869288-64-2
Formulation
A crystalline solid
Purity
≥95%
MW
491,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis.{15630} They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively.{14924} It is 50-250-fold selective for FAK over other protein kinases.{14924} PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.{28528}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
