PF-06447475
CAY-18375-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
1527473-33-1
Formulation
A crystalline solid
Purity
≥98%
MW
305,3
Shipment
-20
Long Term Storage
-20
Shelf Life
730
Description
An LRRK2 inhibitor (IC50 = 3 nM); inhibits LRRK2G2019S (IC50 = 11 nM); inhibits LRRK2 autoactivation in cells (IC50 = 25 nM); inhibits paraquat-induced locomotor deficiencies, decreases in survival, and increases in cranial homogenate levels of MDA in D. melanogaster; increases the number of total and tyrosine hydroxylase-expressing neurons and decreases the number of inducible nitric oxide synthase-expressing neurons in rat SNPC in a transgenic model of Lrrk2G2019S- and α-synuclein-induced model of Parkinson's disease at 30 mg/kg twice per day; reduces levels of macrophage infiltration in the ipsilateral SNPC in the same model at the same dose
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
