PF-06424439
CAY-17680-10 10 mg
Data Sheet: 
CAS
1469284-79-4
Formulation
A crystalline solid
Purity
≥98%
MW
536
Shipment
-20
Long Term Storage
-20
Description
An orally bioavailable inhibitor of DGAT-2 (IC50 = 14 nM); selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC50s = >50 μM); reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner from 0.1-10 mg/kg; reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet at 60 mg/kg per day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
