PF-05105679
CAY-29489-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
1398583-31-7
Formulation
A solid
Purity
≥98%
MW
428,455023
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A TRPM8 antagonist (IC50 = 103 nM for inhibition of voltage-activated currents in HEK293 cells expressing the human receptor); >100-fold selective for TRPM8 over a panel of 90 receptors, ion channels, and enzymes; inhibits cold- and WS-12-induced calcium flux in HEK293 cells expressing the human TRPM8 (IC50s = 480 and 181 nM, respectively); reverses cold-induced reductions in bladder capacity in anesthetized guinea pigs when administered as an i.v. infusion at 46.67 μg/kg per minute; decreases the core body temperature in rats at 100 and 300 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
