NVP-CGM097
CAY-29519-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
1313363-54-0
Formulation
A crystalline solid
Purity
≥98%
MW
659,3
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of the MDM2-p53 interaction (IC50 = 1.7 nM for human MDM2 in a TR-FRET assay); selective for human MDM2 (Ki = 1.3 nM) over dog, mouse, and rat Mdm2 (Kis = 20.5, 65.9, and 47.4 nM, respectively); selectively inhibits proliferation of AML cells expressing wild-type p53 (IC50s = 50-1,000 nM) over AML cells expressing mutant p53 (IC50s = >1,000 nM); induces tumor regression in a PDX mouse model of AML at 100 mg/kg per day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
