NBI 74330
CAY-28442-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
855527-92-3
Formulation
A solid
Purity
≥98%
MW
605,582292
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A CXCR3 antagonist (Ki = 3.6 nM in a radioligand binding assay); inhibits CXCL10- or CXCL11-induced calcium mobilization in RBL cells expressing human CXCR3 (IC50 = 7 nM for both); inhibits CXCL11-induced chemotaxis of CXCR3-expressing H9 cells and PHA/IL-2 T cells (IC50s = 3.9 and 6.6 nM, respectively); reduces peritoneal lymphocyte migration in a mouse model of peritonitis at 100 mg/kg; reduces the size and number of aortic arch atherosclerotic lesions in Ldlr-/- mice; reduces spinal cord microglial activation and levels of CXCL4, CXCL9, and CXCL10 and decreases thermal and mechanical hyperalgesia in a rat model of chronic constriction injury-induced neuropathic pain
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
