
CAS
368449-04-1
Formulation
A crystalline solid
Purity
≥98%
MW
380,35092
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay); selective for telomerase over DNA polymerase (3 μM); inhibits growth of U937 cells (GI50 = 1.7 μM); reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells; decreases survival of H460 and H1299 NSCLC cells; reduces tumor size by 70% in an H460 mouse xenograft model (40 mg/kg); inhibits replication of HSV-2 and a clinical isolate of HSV-1; decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).