LY354740
CAY-24215-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
176199-48-7
Formulation
A crystalline solid
Purity
≥95%
MW
185,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A group II mGluR agonist (Kis = 99 and 94 nM, respectively); inhibits forskolin-stimulated cAMP accumulation in cells expressing human mGluR2 and mGluR3 (EC50s = 5.1 and 24.3 nM, respectively); highly selective for mGluR2 and mGluR3 over mGluR4, mGluR7, mGluR1a, and mGluR5a (EC50s = >100 µM); suppresses electrically stimulated EPSPs in rat striatal neurons in vitro (EC50 = 20 nM); suppresses serotonin-induced EPSCs in rat medial prefrontal cortex in vitro (EC50 = 89.1 nM); attenuates the effects of PCP on working memory, stereotypy, locomotion, and cortical glutamate efflux in a rat model of schizophrenia (10 mg/kg); shows efficacy in animal models of anxiety, epilepsy, and withdrawal from nicotine and morphine
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
