LX2343
CAY-27799-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
333745-53-2
Formulation
A solid
Purity
≥98%
MW
474,91484
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of BACE1 and PI3K (IC50s = 11.43 and 15.99 μM, respectively); inhibits STZ-induced accumulation of Aβ40 and Aβ42 in both HEK293-APPSW and CHO-APP cells in a concentration-dependent manner; inhibits STZ-induced increases in JNK and APPThr668 phosphorylation as well as sAPPβ protein levels; reduces levels of Aβ40 and Aβ42, as well as thioflavine S staining, in cortex and hippocampus in the APP/PS1 transgenic mouse model of Alzheimer’s disease at 10 mg/kg/day; reduces cortical levels of p62 protein and PI3K, Akt, and mTOR phosphorylation; decreases path length and escape latency time in the Morris water maze in APP/PS1 mice at 10 mg/kg/day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
