KRAS(G12C) Nucleotide Exchange Assay Kit
BPS-79859-2 384 rxns.
Data Sheet: 
Applications
Useful for screening small molecular inhibitors/antagonists that are expected to affect the KRAS(G12C)-GDP or -GTP binding status for drug discovery and HTS targeting of KRAS(G12C).
Shipment
-80°C (dry ice)
Literature References
1. Ostrem, J. M., et al., Nature. 2013; 503:548-551.
2. Patricelli, M. P., et al., Cancer Discovery. 2016; 6:316-329
2. Patricelli, M. P., et al., Cancer Discovery. 2016; 6:316-329
Description
The KRAS(G12C) Nucleotide Exchange Assay Kit is designed for screening and profiling of KRAS(G12C) antagonists/inhibitors by using BODIPY-GDP to monitor the GDP or GTP binding status. The kit can be used with two different protocols for greater flexibility, either titrating the inhibitor with fixed GTP concentration or titrating the GTP with fixed inhibitor concentration.
- Useful for screening small molecular inhibitors/antagonists that are expected to affect the KRAS(G12C)-GDP or -GTP binding status for drug discovery and HTS targeting of KRAS(G12C). - Avoid freeze/thaw cycles.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
