Isosakuranetin
CAY-25198-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
480-43-3
Formulation
A crystalline solid
Purity
≥98%
MW
286,27936
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A citrus flavanone with diverse biological activities; inhibits PregS-induced calcium uptake in HEK293 cells expressing mouse TRPM3 (IC50 = 50 nM); selective for TRPM3 over TRPM1, TRPM8, and TRPV1 at 10 µM; increases latency to first pain-related response in mice in a hot plate test and reduces the number and duration of PregS-induced nocifensive responses in mice at 2 mg/kg; reduces systolic blood pressure in spontaneously hypertensive rats at 10 mg/kg; inhibits UV-B-induced MMP-1 expression by 90% in HaCaT cells at 20 µM and inhibits phosphorylation of ERK1/2 at 50 µM; blocks hydrogen peroxide-induced increases in ROS, intracellular calcium concentration, caspase-3 activity, and JNK phosphorylation, as well as decreases in catalase activity, in PC12 cells at 0.8 µM; has antibacterial and trypanocidal activity against M. tuberculosis, C. neoformans, and T. cruzi
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
