INF39
CAY-28476-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
866028-26-4
Formulation
A solution in ethanol
Purity
≥98%
MW
224,7
Shipment
-20
Long Term Storage
-20
Shelf Life
730
Description
An irreversible inhibitor of the NLRP3 inflammasome; inhibits activation of caspase-1 and release of IL-1β and LDH induced by ATP or nigericin in LPS-primed BMDMs at 10 µM; reduces ATP-induced pyroptosis in LPS-primed THP-1 cells by 33.6% at 10 µM; prevents increases in IL-1β protein levels induced by DNBS in the colon in a rat model of colitis; reduces the severity of pancreatic lesions and serum levels of IL-1β, TNF-α, and IL-6 during caerulein- and LPS-induced pancreatitis in mice at 25 and 50 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
