INCB 3344
CAY-28433-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
1262238-11-8
Formulation
A solid
Purity
≥95%
MW
577,592089
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An antagonist of CCR2 (IC50 = 10 nM); selective for CCR2 over a panel of G protein-coupled receptors, including CCR1 and CCR5, with IC50s values >1 µM; inhibits MCP-1-induced chemotaxis of WEHI-274 cells (IC50 = 10 nM); inhibits monocyte influx in a thioglycolate-induced mouse model of peritonitis at 60 and 100 mg/kg; decreases the expression of CCR2 mRNA in the ear and reduces ear swelling in a mouse model of delayed-type hypersensitivity reaction at 30, 50, and 100 mg/kg twice per day; prevents increases in or reduces macrophage levels in the spinal cord at 100 mg/kg per day beginning the day of immunization or seven days following immunization, respectively, in a mouse model of EAE
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
