IL-38 (human) (rec.) (His)
AG-40A-0191Y-C010 10 ug
Synonyms: Interleukin-38; Interleukin-1 Family Member 10 theta; IL-1F10; FIL1 theta; FKSG75; IL-1HY2; IL1-theta; Interleukin-1 HY2; Interleukin-1 Receptor Antagonist FKSG75
Data Sheet: 
SDS:
SDS:
Reactivity
Human
Source / Host
E. coli
Purity
>95% (SDS-PAGE)
MW
~18kDa (SDS-PAGE)
Shipment
BI
Short Term Storage
+4°C
Long Term Storage
-20°C
Shelf Life
Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.After reconstitution, prepare aliquots and store at -20°C.
Description
Recombinant protein. Human IL-38 (aa 1-152) is fused at the C-terminus to a His-tag. Source: E. coli. Lyophilized. In 50mM TRIS-Cl, pH 8.0, containing 150mM NaCl. IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
