IL-11 Responsive Luciferase Reporter HEK293 Line
BPS-83014 2 vials
Synonyms: Adipogenesis inhibitory factor, Oprelvekin, IL11, IL11RA, Interleukin-11 receptor subunit alpha
Data Sheet: 
Reactivity
Human
Applications
Useful for screening for modulators of IL-11 mediated signaling pathways.
Source / Host
human
Shipment
-80°C
Literature References
Campbell C., et al., 2001 Am J Pathol. 158(1):25-32.
Cook S., et al., 2020 Annu Rev Med. 71:263-276.
Fung K., et al., 2022 Cytokine. 149:155750.
Jones S., et al., 2018 Nat Rev Immunol. 18(12):773-789.
Lokau J., et al., 2021 Biochim Biophys Acta Mol Cell
Description
The IL-11 (Interleukin-11) Responsive Luciferase Reporter HEK293 Line is a HEK293 cell line engineered to express both human IL-11Ra (IL-11 receptor alpha) (NM_001142784.3) and human IL-6ST (IL-6 cytokine family signal transducer, also known as gp130) (NM_002184.4) separated by a self-cleaving P2A peptide. The construct was delivered by lentiviral transduction of STAT3 Luciferase Reporter HEK293 Cell Line (#79800-P), which express a firefly luciferase reporter driven by STAT3 response elements located upstream of the minimal TATA promoter. After activation by IL-11, the endogenous transcription factor STAT3 binds to the response elements, inducing transcription of the luciferase reporter gene.
This cell line has been validated to respond to IL-11.
Figure 1: Illustration of the mechanism of action in the IL-11 Responsive Luciferase Reporter HEK293 Cell Line.Interested in screening and profiling inhibitors, blocking antibodies, or activators of IL-11 signaling without the need to purchase and license the cell line? Check out our Cell Signaling Pathway Screening. - Useful for screening for modulators of IL-11 mediated signaling pathways. - Avoid freeze/thaw cycles.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
