Human TARC (CCL17) ELISA
BLA-BA1033 96 wells
Synonyms: thymus and activation-regulated chemokine
Data Sheet: 
Sample Type
Serum, Plasma
Assay Range
2000 - 20 pg/ml
Description
TARC (thymus and activation-regulated chemokine), also known as C-C motif chemokine ligand 17 (CCL17), is expressed in the thymus and is produced by dendritic cells, endothelial cells, keratinocytes, and fibroblasts1. TARC has affinity as a ligand for the C-C chemokine receptors CCR4 and CCR8 inducing Th2-dominant inflammatory reactions.
TARC has an important role in allergic diseases such as atopic dermatitis and bronchial asthma2,3. High serum concentrations of TARC are observed in patients with atopic dermatitis, and its concentration reflects the disease activity 4,5. The concentration of TARC is also reported to be elevated in sputum of patients with bronchial asthma6, and TARC may have potential as a therapeutic target. In clinical practice, TARC is useful also in selection of patients requiring new therapies of atopic dermatitis or asthma.7
Enzyme Immunoassay for the quantitative determination of TARC in human serum.
RESOURCES
Saeki, H. & Tamaki, K. Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases. J. dermatological Sci. 43, 75–84, (2006)
Hamilton JD et al. Dupilumab suppresses type 2 inflammatory biomarkers across multiple atopic, allergic diseases. Clin Exp Allergy 51(7):915-931 (2021)
Yamada A, Kiryu K, Takashino S, Yoshida M, Takeichi T, Kitamura O. Diagnostic value of serum thymus and activation-regulated chemokine (TARC) in fatal asthma. Forensic Sci Int. 365:112276 (2024)
Kakinuma, T. et al. Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity. J. allergy Clin. immunology 107, 535–541, (2001).
Dekkers C et al. Tralokinumab Treatment in Adult Atopic Dermatitis Patients: 28-Week Evaluation of Clinical Effectiveness, Safety, Serum Proteins and Total IgE Levels. Allergy. Ahead of print. https://doi.org/10.1111/all.16414 (2024)
Sekiya, T. et al. Increased levels of a TH2-type CC chemokine thymus and activation-regulated chemokine (TARC) in serum and induced sputum of asthmatics. Allergy 57, 173–177 (2002)
Kataoka Y. Thymus and activation-regulated chemokine (CCL17) as a clinical biomarker in atopic dermatitis: significance and limitations in the new treatment era. Front Allergy 5:1473902 (2025)
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
