Gefapixant
CAY-40825-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
1015787-98-0
Formulation
A solid
Purity
≥98%
MW
353,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A P2X3 receptor antagonist; inhibits agonist-induced P2X3 and P2X2/3 currents in 1321N1 cells co-expressing human P2X2 and P2X3 (IC50s = 153 and 220 nM, respectively) but does not inhibit P2X2 currents in the same cells at 10 µM; increases the paw withdrawal threshold and decreases weight-bearing discomfort in a rat model of CFA-induced inflammatory hyperalgesia and a rat model of neuropathic pain induced by sciatic nerve injury at 30 mg/kg; improves cardiac function, reduces cardiac TNF-α levels, and prevents cardiac fibrosis in a rat model of LAD branch ligation-induced myocardial infarction induced at 10 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
