G007-LK
CAY-22934-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
1380672-07-0
Formulation
A crystalline solid
Purity
≥98%
MW
530
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A TNKS1/2 inhibitor (IC50s = 46 and 25 nM, respectively); selective for TNKS1 and TNKS2 over a panel of 90 kinases, 16 phosphatases, and 73 GPCRs; inhibits colony formation of COLO 320 DM and SW403 cells (200 µM); inhibits colony formation of HCC cells in a dose-dependent manner; increases differentiation marker expression in COLO 320 DM and HCT15 cells (100 nM); inhibits Wnt signaling in HEK293 and 10T1/2 cells in a dose-dependent manner; inhibits tumor growth in COLO 320 DM and SW403 mouse xenograft models (20 mg/kg, i.p., twice daily) but leads to moribundity and death at a dose of 30 mg/kg twice daily
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
