Fluzoparib
CAY-36671-50 50 mg
Data Sheet: 
SDS:
SDS:
CAS
1358715-18-0
Formulation
A solid
Purity
≥98%
MW
472,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A PARP1 inhibitor (IC50 = 1.46 nM); induces DNA double-strand breaks in wild-type, but not BRCA2-/-, V-C8 cells, as well as BRCA1-/- MDA-MB-436 cells at 1 and 10 µM; inhibits the proliferation of BRCA2-/- V-C8 cells (IC50 = 0.053 µM), BRCA1-/- MDA-MB-436, UWB1.289, and MX-1 cells (IC50s = 0.51, 1.57, and 1.57 µM, respectively), and OVCAR-8 cells containing hypermethylated BRCA1 (IC50 = 1.43 µM); reduces tumor formation in an MDA-MB-436 mouse xenograft model at 1 and 3 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
