Flavopiridol (hydrochloride)
CAY-10009197-5 5 mg
Synonyms: Alvocidib|HL 275|HMR 1275|L-868,275
Data Sheet: 
SDS:
SDS:
CAS
131740-09-5
Formulation
A crystalline solid
Purity
≥95%
MW
438,3
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of cyclin-dependent kinases (Cdks; IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively); inhibits TEFb (Ki = 3 nM); inhibits transcription of a CMV promoter in HeLa nuclear extract (IC50 = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC50 = 7 nM), and HIV-1 replication in HEK239T cells (IC50 = <10 nM); induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model at 5 mg/kg; suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
