
CAS
1094-08-2
Formulation
A solid
Purity
≥98%
MW
348,93398
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A BChE inhibitor (IC50 = 15.14 µM in human erythrocyte lysates); selective for BChE over AChE at 500 µM; binds to rat forebrain and hindbrain membrane preparations (Kis = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M1 and M2 muscarinic acetylcholine receptors, respectively; decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with ZM 241395 at 0.232 mg/kg; reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation at 20 and 30 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).