Emricasan
CAY-22204-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
254750-02-2
Formulation
A crystalline solid
Purity
≥95%
MW
569,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A pan-caspase inhibitor; prevents cold ischemia-warm reperfusion-induced SEC apoptosis and inhibits caspase-3 activation in rat liver at 10 mg/kg ex vivo; reduces ALT levels (ED50s = <0.01-0.38 mg/kg) as well as apoptosis and caspase activity in a dose-dependent manner in the α-Fas mouse and D-Gln/LPS rat models of liver injury; reduces caspase-3 and caspase-8 activity, serum ALT levels, hepatocyte apoptosis, and hepatic fibrogenesis in a mouse model of high-fat diet-induced NASH; enhances islet engraftment and lowers post-transplant fasting glucose levels in a porcine islet autotransplant model
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
