Elafibranor
CAY-23508-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
923978-27-2
Formulation
A solid
Purity
≥98%
MW
384,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An agonist of PPARα and PPARδ; increases HDL secretion and expression of lipid-related genes ABCA1, PLIN-2, and ABHD5 in Caco-2/TC7 cells in a PPARα-dependent manner; decreases levels of plasma triglycerides and total cholesterol while increasing plasma HDL and expression of Acox1 in the liver of ApoE2-KI wild-type, but not PPARα knockout, mice fed a Western diet when administered at a dose of 10 mg/kg; reduces diet-induced macro- and micro-steatosis in a PPARα-deficient mouse model of non-alcoholic steatohepatitis; reduces cholesterol and triglyceride accumulation as well as macrovesicular steatosis in the liver of insulin-resistant db/db mice fed the MCD diet
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
