Efaproxiral
CAY-28294-500 500 mg
Data Sheet: 
SDS:
SDS:
CAS
131179-95-8
Formulation
A crystalline solid
Purity
≥98%
MW
341,40096
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An allosteric Hb modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue; increases p50 from 26.75 to 38.63 mm Hg and decreases the percent Hb-O2 saturation from 48 to 33.8% at a pO2 of 26 mm Hg in isolated human whole blood at 1.75 mM; increases tumor pO2 from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model at 150 mg/kg; enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions at 100 μM; increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model at 100 mg/kg; increases the running capacity of normal mice and mice with LCA ligation-induced MI at 150 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
