Edicotinib
CAY-33347-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
1142363-52-7
Formulation
A crystalline solid
Purity
≥98%
MW
461,5993
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A CSF1R inhibitor (IC50 = 3.2 nM); selective for CSF1R over KIT and FLT3 (IC50s = 20 and 190 nM, respectively); reduces CSF1-induced phosphorylation of CSF1R and ERK1/2 in N13 microglia at 0.1-1,000 nM; reduces spinal motor neuron degeneration and increases the latency to fall in the rotarod test in the P301S mouse model of tauopathy; reduces increases in the colonic weight to length ratio, as well as decreases colonic infiltration of macrophages, neutrophils, and CD3+ T cells, in an adoptive T cell transfer-induced mouse model of colitis at 15 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
