EP4 Receptor Antagonist 1
CAY-32722-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
2287259-07-6
Formulation
A crystalline solid
Purity
≥98%
MW
458,433209
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An EP4 receptor antagonist (IC50 = 6.1 nm in a calcium flux assay); selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10,000 nM for all); reverses PGE2-induced ERK phosphorylation in EP4-expressing CHO cells and decreases GM-CSF-induced expression of Il1b, Il4ra, Il6, Arg1, Cox2, and Il10 in RAW 264.7 cells at 10 µM; reduces tumor volume and increases infiltration of CD8+ T cells into tumors in a murine colon carcinoma model at 50 and 150 mg/kg once per day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
