E6446 (hydrochloride)
CAY-37296-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
1345675-25-3
Formulation
A solid
Purity
≥95%
MW
522,5065
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A TLR7 and TLR9 antagonist (IC50s = 1.78 and 0.01 µM, respectively); selective for TLR7 and TLR9 over TLR4 (IC50 = 10.58 µM); inhibits CpG ODN2216- or RNA40-induced IL-6 production in isolated mouse BMDCs; prevents increases in left ventricle chamber size and cardiac fibrosis in a mouse model of transverse aortic constriction-induced heart failure at 1.5 mg/animal; increases survival and reduces increases in right ventricular systolic pressure and hypertrophy in a rat model of monocrotaline-induced pulmonary hypertension at 10 mg/kg; has been used to enhance the transfection efficiency of cell-penetrating peptides for the delivery of mRNA in vitro
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
