Dehydrolithocholic Acid
CAY-29544-100 100 mg
Synonyms: 3-keto LCA|3-keto Lithocholate|3-keto Lithocholic Acid|3-KLCA|3-oxo LCA|3-oxo Lithocholate|3-oxo Lithocholic Acid
Data Sheet: 
SDS:
SDS:
CAS
1553-56-6
Formulation
A crystalline solid
Purity
≥95%
MW
374,55672
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A major metabolite of lithocholic acid; formed from LCA by CYP3A4; an agonist of TGR5 (EC50 = 0.27 μM), VDR (EC50 = 3 μM), and FXR in cell-based reporter assays; binds to human PXR (IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays at 100 μM; binds to RORγt (Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay at 10 μM; inhibits the differentiation of TH17 cells at 20 μM
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
