CAS
96946-42-8
Formulation
A crystalline solid
Purity
≥98%
MW
1243,48126
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A competitive antagonist of nAChRs and non-depolarizing muscle relaxant; inhibits acetylcholine stimulation of human adult muscle nAChRs (IC50 = 10 nM); inhibits mouse nAChRs (IC50s = 54 and 115 nM for adult and embryonic receptors, respectively); increases apoptosis in HUVEC cells; decreases proliferation of HepG2 and HUVEC cells in vitro; reduces the magnitude of electrically-evoked twitch tensions in isolated rat extensor digitorum longus and soleus sciatic nerve-muscle preparations; blocks electrically-evoked muscle twitches in anesthetized rabbits (ED95 = 0.04 mg/kg)
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).