CX-4945 . hydrochloride [Silmitasertib . HCl]
AG-CR1-3629-M001 1 mg
Synonyms: Silmitasertib . HCl; 8-Carboxy-N-(3-chlorophenyl)benzo[c][2,6] naphthyridin-5-aminium chloride
![CX-4945 . hydrochloride [Silmitasertib . HCl]](/images/loghi/NoImage-logoVB.png "CX-4945 . hydrochloride [Silmitasertib . HCl]")
Data Sheet: 
SDS:
SDS:
CAS
1009820-21-6 (free acid)
Purity
>98%
MW
349.8 . 36.5 . x18.0
Shipment
Ambient
Short Term Storage
+4°C
Long Term Storage
-20°C
Shelf Life
Stable for at least 2 years after receipt when stored at -20°C.
Description
Chemical. CAS: 1009820-21-6 (free acid). Formula: C19H12ClN3O2 . HCl. MW: 349.8 . 36.5. Synthetic. Orally active, potent and selective ATP-competitive inhibitor of the protein kinase CK2 (IC50=1nM). Anticancer compound. Inhibits proliferation in a panel of cancer cell lines that overexpress CK2. Inhibited migration, blocks survival and induces apoptosis in cancer stem cells, glioblastomas and leukemia cells. Shown to decrease the glucose metabolism in cancer cells. Potent inhibitor of Cdc2-like kinases (Clks) in vitro, consequently interfering with alternative splicing. Potent ATP-competitive inhibitor of DYRK1A (IC50=6.8 nM), involved in neurodegenration-associated diseases. CK2alpha deletion selectively increased M3 muscarinic receptors (M3Rs)-mediated insulin secretion from pancreatic islets. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
