CDKI-73
CAY-41099-5 5 mg
CAS
1421693-22-2
Formulation
A solid
Purity
≥98%
MW
394,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of Cdk9/cyclin T1, Cdk1/cyclin B, and Cdk2/cyclin A complexes (Kis = 4, 4, and 3 nM, respectively); selective for these complexes over the Cdk7/cyclin H complex (Ki = 91 nM); cytotoxic to HCT116 cells (GI50 = <10 nM); induces apoptosis in COLO 205, HCT116, HT-29, and KM12 cells at 0.25 or 1 µM; reduces the levels of Bcl-2, cyclin D1, and Mcl-1, as well as decreases the mitochondrial membrane potential, in HCT116 cells at 0.25 µM; decreases tumor volume in an HCT116 mouse xenograft model at 100 mg/kg every three days
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
